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Forward and inverse problems in the acute myocardial ischemia

B. Milan Horacek
Robert S. Macleod
Joshua L. Leon
Jukka Neonen
BM

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B. Milan Horacek

Résumé du colloque

We tried to solve both the forward and inverse problems of electrocardiography to understand better the relationship between epicardial and body surface potentials in specific cases of controlled acute ischemia produced during coronary angioplasty. In the forward solutions, we simulated ischemic conditions in an anisotropic realistically shaped model of the human ventricles. The heart’s primary electric sources were determined according to the anisotropic bidomain theory; the secondary sources, arising due to boundary conditions, were evaluated by the boundary-element method. As a result, we obtained simulated body-surface potentials that could be compared with corresponding measurements in patients undergoing coronary angioplasty. In the inverse solution, we used measured body-surface potentials to calculate epicardial potentials; the solution was implemented in model with 700 body-surface and 400 epicardial-surface triangles, and it employed Tikhonov zero-order regularization. The estimated location of the ischemic region yielded by the inverse solution correlated well with the site of coronary occlusion determined by digital-subtraction angiography. To obtain an estimate of the ischemic region size, we attempted to evaluate myocardial perfusion by single photon emission tomography and the new radioactive tracer technetium-99m-sestamibi.

Contexte

Section :
(Le) Problème inverse de l’électrocardiographie
news icon Thème du colloque :
(Le) Problème inverse de l’électrocardiographie
host icon Hôte : Université de Montréal

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(Le) Problème inverse de l’électrocardiographie
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Thème du colloque :

(Le) Problème inverse de l’électrocardiographie
Forward and inverse problems in the acute myocardial ischemia
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Forward and inverse problems in the acute myocardial ischemia
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Forward and inverse problems in the acute myocardial ischemia
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