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Les résidus de substances organiques polluantes sont en croissance dans le fœtus et le placenta humain

GC

Membre a labase

Gerard Cooke

Résumé de la communication

Persistent organic pollutants (POPs) found in the environment, wildlife, food, water, house dust, human tissues and fluids may alter normal physiological activities during the human lifespan. While the levels of some POPs (polychlorinated biphenyls [PCBs] and organochlorines [OCs]) in these matrices have decreased following their banning, others (brominated diphenyl ethers [BDEs]) have increased in recent years. In order to determine the longitudinal trend of specific POPs in human fetal tissues, early to mid-gestation fetal liver (n=52) and placental (n=60) tissues were obtained following elective abortions during 1998-2006 and were analyzed for selected BDEs, PCBs and OCs using gas chromatography¡Vmass spectroscopy methodology. Fetal liver total BDE levels increased over time (1998: 284.4ƒy229.8ng/g lipid [M+SE]; 2006: 1607.7ƒy605.9; p<0.03) while placental levels were generally lower and no clear trend was evident. Low levels of PCBs and OCs varied yearly with no evident trend. The major analytes in 1998 were OCs (liver: 49%; placenta: 71%), while the major analytes in 2006 were BDEs (liver: 89%; placenta: 98%). The 1998-2006 tissue BDE congener profile is similar to that of the DE-71 commercial BDE mixture manufactured in North America. While commercial production of BDEs in North America was halted in 2004, their concentrations in fetal liver and placentae are now greater than the tissue burdens for the analyzed OCs and PCBs.

Résumé du colloque

Ce colloque de l'ACFAS sera le deuxième parrainé par le Réseau Québécois en reproduction, un réseau récemment formé qui comprend près de 60 chercheurs québécois dans le domaine de la reproduction.

Contexte

host icon Hôte : Université de Montréal

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