Colloque

Passive Transfer of Anaphylactoid Hypersensitivity in Rats

P. Sacra

Vincent Adamkiewicz

Membre a labase

P. Sacra

Résumé du colloque

Dextran anaphylactoid hypersensitivity has been transferred passively. Donor rats were injected with dextran (12 mg/100 mg/b.w.); 60 mins later 5 cc of blood was taken from the ventral aorta. A second group of acceptor rats was then injected i.v., with 0.5 cc of serum from the previous group; this second group showed a typical anaphylactoid reaction. The optimum time of transfer, plus experiments with radioactive dextran, demonstrate that the anaphylactoid reaction that occurs in the acceptor rats is produced by a substance other than dextran. Pre-sensitization of donors potentiates the passively transferable factor.