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The chemical composition of environmental samples such as airborne particulate matter is very complex, consisting of hundreds of organic and inorganic components. Over the last decade considerable effort has been directed to the determination of the levels of known carcinogenic compounds, particularly polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, in the organic solvent extractable fraction. In recent years, however, it has become clear from work with microbial mutagenesis assays and chemical fractionation techniques that there are many hazardous substances present in the environment and the workplace that are still largely uncharacterized. Studies have shown that much of the mutagenic activity …
