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Colloque
Dextran anaphylactoid hypersensitivity has been transferred passively. Donor rats were injected with dextran (12 mg/100 mg/b.w.); 60 mins later 5 cc of blood was taken from the ventral aorta. A second group of acceptor rats was then injected i.v., with 0.5 cc of serum from the previous group; this second group showed a typical anaphylactoid reaction. The optimum time of transfer, plus experiments with radioactive dextran, demonstrate that the anaphylactoid reaction that occurs in the acceptor rats is produced by a substance other than dextran. Pre-sensitization of donors potentiates the passively transferable factor.
Colloque
Rats were sensitized with three i.p. injections of horse serum or egg-white, and received the shocking dose on the 21st day; a typical anaphylactic shock developed. This shock can be aggravated or inhibited by varying the glycemic state of the animal. Hyperglycemia is achieved by two s.c. injections of 5 cc of 25% glucose, two hours and one hour prior to the shocking dose. Hypoglycemia was achieved by 4 1/rat of insulin s.c. 30 mins prior to the shocking dose. Hypoglycemic rats suffered a more severe shock, while hyperglycemic animals were protected. The histological studies of the shock organs confirm …
