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Rats were sensitized with three i.p. injections of horse serum or egg-white, and received the shocking dose on the 21st day; a typical anaphylactic shock developed. This shock can be aggravated or inhibited by varying the glycemic state of the animal. Hyperglycemia is achieved by two s.c. injections of 5 cc of 25% glucose, two hours and one hour prior to the shocking dose. Hypoglycemia was achieved by 4 1/rat of insulin s.c. 30 mins prior to the shocking dose. Hypoglycemic rats suffered a more severe shock, while hyperglycemic animals were protected. The histological studies of the shock organs confirm …
