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Nous avons fait une étude histochimique comparée des divers types de lésions du myocarde provoquées chez le rat par l'administration d'amines toxiques, d'agents mobilisateurs de calcium et par l'occlusion de la circulation coronarienne. Du point de vue histologique, ces lésions diffèrent selon qu'elles résultent d'une anoxie plus ou moins profonde du myocarde ou d'une action myotoxique directe de la substance administrée. La diminution du glycogène des fibres cardiaques est l'indice le plus précoce des cardiopathies anoxiques ; par contre, le glycogène aura plutôt tendance à augmenter de façon transitoire dans les cardiopathies toxiques. On observe également, au cours de ces …
Calcifying cardiopathies were induced by the administration of paraphenylenediamine and of plasmocid as well as by surgical occlusion of coronary veins, in the rat. In all these cases, the intensity of myocardial calcification, unlike the onset of necrosis, was greatly enhanced by parathyroidectomy. On the other hand, the aggravating action of parathyroid deficiency was counteracted by simultaneous thyroidectomy, and the administration of thyroxine offered no replacement value in this respect. It was also observed that the administration of dihydrotachysterol, a well known calcifying agent, can actually prevent myocardial calcification in both intact and parathyroidectomized animals. An interpretation of these findings …
Calcifying cardiopathies were induced by the administration of paraphenylenediamine and of plasmocid as well as by surgical occlusion of coronary veins, in the rat. In all these cases, the intensity of myocardial calcification, unlike the onset of necrosis, was greatly enhanced by parathyroidectomy. On the other hand, the aggravating action of parathyroid deficiency was counteracted by simultaneous thyroidectomy, and the administration of thyroxine offered no replacement value in this respect. It was also observed that the administration of dihydrotachysterol, a well known calcifying agent, can actually prevent myocardial calcification in both intact and parathyroidectomized animals. An interpretation of these findings …