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Long-term potentiation of excitatory synaptic responses in hippocampal CA1 pyramidal neurons is accompanied by changes in GABAergic inhibition mediated by local interneurons. Past work in our laboratory showed that polysynaptic IPSPs in pyramidal cells are potentiated to a greater extent when theta-burst stimulation (TBS) rather than 100 Hz tetani is used to induce LTP. To determine if the potentiation is due partly to direct strengthening of inhibitory synaptic transmission, we examined changes in pharmacologically isolated monosynaptic IPSPs in CA1 pyramidal cells following either TBS or 100 Hz tetanization. In experiments with sharp electrodes filled with 4M KAc and 0.01M KCl, …
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Long-term potentiation of excitatory synaptic responses in hippocampal CA1 pyramidal neurons is accompanied by changes in GABAergic inhibition mediated by local interneurons. Past work in our laboratory showed that polysynaptic IPSPs in pyramidal cells are potentiated to a greater extent when theta-burst stimulation (TBS) rather than 100 Hz tetani is used to induce LTP. To determine if the potentiation is due partly to direct strengthening of inhibitory synaptic transmission, we examined changes in pharmacologically isolated monosynaptic IPSPs in CA1 pyramidal cells following either TBS or 100 Hz tetanization. In experiments with sharp electrodes filled with 4M KAc and 0.01M KCl, …
